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World's leading geneticists call for investigation into deeply disturbing claims

In a statement wrapping up the Second International Summit on Human Genome Editing in Hong Kong, the event's organizing board…

In a statement wrapping up the Second International Summit on Human Genome Editing in Hong Kong, the event’s organizing board said He Jiankui’s research was “irresponsible” and called for an assessment to “verify this claim and to ascertain whether the claimed DNA modifications have occurred. “

He, an associate professor at the Southern University of Science and Technology in Shenzhen, sent shock waves through the scientific community on Monday when he announced in a video posted online that two ostensibly healthy twin girls had been born this

The board, made up of 14 leading geneticists from around the world, warned that even if He’s claims were verified, the procedure failed to conform to international norms.

” Dens flaws inkluderer en inadequatisk medicinsk indikation, en fattigt designet studieprotokol, en manglende opfyldelse af etiske normer for beskyttelse af velfærdens forskningsfag, og en mangel o

Presenting his findings for the first time at the summit on Wednesday, He publicly defended his work, saying he felt “proud” of his Achievement. He also raised the possibility of a third child being born after announcing that a separate woman was pregnant at an early stage with a modified embryo.

 Chinese scientist He Jiankui at the Second International Summit on Human Genome Editing in Hong Kong on November 28, 2018.

He’s research has raised serious ethical questions about the transparency of gen editing and sparked calls from some attending the event for a globally binding code of conduct.

Clinical use of genetic editing ‘irresponsible’

Scientists reiterated an agreement made at the previous conference in 2015 that said it would be irresponsible to Gebruik dergelijke genetische bewerking totdat veiligheidskwesties waren behandeld.

“While we applaud the rapid advance of somatic gene editing into clinical trials, we continue to believe that any clinical use of germline editing remains irresponsible at this time,” the statement said.

Germline gene-editing refers twee genetische veranderingen in elke cel, die zal worden doorgegeven aan toekomstige generaties.

Conference Chairman and Nobel laureate David Baltimore acknowledged that verifying He’s claims would be challenging as No one knows who or where his subjects are.

“We have called for an investigation but we have not laid out how to do it, because it depends on what kind of cooperation we get from him,” Baltimore said.

Separately, He is the subject of an investigation by the Chinese government.

 Chinese scientist's risky experiment with gene-editing babies

In a joint statement issued Monday, more than 120 Chinese scientists condemned He’s using the CRISPR-Cas9 gene-editing tool as a “big blow” to the reputation of Chinese biomedical research.

“It’s extremely unfair to Chinese scientists who are diligent, innovative og de forsvinner de nederste linjer af videnskabelig etik, “de skrev, tilføjer at” direkte eksperimentering på mennesker er ingenting men galt. “

Både det hospital som er nævnt i hans etiske godkendelsesdokumenter, og universitetet er affilieret med, har nægtet nogen involvement in the procedures.

Organizers on Thursday proposed establishing standards for preclinical evidence and accuracy of gene modification that include “enforceable standards of professional behavior.”

Currently, each country has their own

Scientific community ‘needs to do more’

Speaking in a question-and-answer session after He’s presentation on Wednesday, Baltimore said the case showed that ” Der har været en fiasko for selvregulering af det videnskabelige samfund på grund af manglen på gennemsigtighed. “

At Han kunne tinker med livet, der ændrede teknologien væk fra tilsynsmyndighedernes øjne, har fanget mange i det videnskabelige samfund på ryggen.

“We did not know this was coming,” Jennifer Doudna, professor of chemistry and molecular and cell biology at UC Berkeley and one of the co-inventors of CRISPR told CNN.

“I hope this is a wake up call for everybody to recognize that while this technology is incredibly exciting, this is an important moment where we need to grapple with the responsibility of managing this technology going forward.”

Days before The conference Feng Zhang, also a co-inventor CRISPR, and member of the Broad Institute of MIT and Harvard, called for a moratorium on using the technology to edit the genes of babies.

“The technology is still very early and there are many challenges that need to be resolved,” he told CNN. Zhang erkendde dat het reguleren van deze soort onderzoek zou moeilijk zijn, maar zei dat het belangrijk was om te komen tot een reeks van vereisten voor het opstellen van een uitgebreide en informatieve applicatie voor experimentele geneeskundeontwikkeling. “

” We can do more on that front, “he said.

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