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Why the combination of probiotics and antibiotics is good for sores

A combination of probiotics and antibiotics can eradicate two strains of drug resistant bacteria that often infect sores. According to…

A combination of probiotics and antibiotics can eradicate two strains of drug resistant bacteria that often infect sores.

According to researchers at the Massachusetts Institute of Technology, if the combination of probiotics / antibiotics proved successful in future tests in animals and humans, it may be incorporated into wounds where it can help heal infected chronic wounds. The study was published in Advanced Materials.

“There are so many bacteria that are now resistant to antibiotics, which is a serious problem for human health. We believe that one way to treat them is to enclose a living probiotic and let it do their job,” says Ana Jaklenec .

The human body contains trillions of bacterial cells, many of which are beneficial. In some cases, these bacteria help prevent infection by secreting antimicrobial peptides and other compounds that kill pathogenic bacterial strains. Others fight harmful strains by absorbing nutrients and other critical resources.

Researchers have previously tested the idea of ​​applying probiotics to chronic wounds, and they have been successful in studying patients with burns, says senior writer Zhihao Li. However, the probiotic strains usually do not control all bacteria that would be found in an infected wound. Combining these strains with traditional antibiotics would help kill more of the pathogenic bacteria, but antibiotics were also likely to kill the probiotic bacteria.

The MIT team designed a way to circumvent this problem by encapsulating the probiotic bacteria so that they would not be affected by the antibiotic. In addition, researchers found that alginate is a part of the biofilm that the bacteria form to protect themselves from antibiotics.

The researchers believe that this method can be used to develop new types of bandages or other wound dressings embedded with antibiotics and alginate-encapsulated probiotics.

(This story has not been edited by Business Standard staff and is automatically generated from syndicate feed.)


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