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“Trojan horse” antibiotic effective against drug resistant bacteria – researcher

A new antibiotic that acts as a "Trojan horse" has proven to be effective against drug resistant bacteria, researchers have…

A new antibiotic that acts as a “Trojan horse” has proven to be effective against drug resistant bacteria, researchers have said.

Researchers say attempts at 448 people with kidney or urinary tract infections found the drug cefiderocol eradicated bacteria as effective as current treatments.

The drug triggers bacterial biology by tying iron to enter cells – which acts as the Trojan horse who used to sneak the ancient Greeks to Troy.

Experts say that the results of the research highlight the potential of cefiderocol as a new alternative for the treatment of highly resistant bacteria.

Research leader Dr. Simon Portsmouth, Shionogi Inc, said: “Cefiderocol proved to be both safe and tolerable in a population of elderly patients who were very ill with complex conditions and a wide range of multiresistant pathogens.

“Our results support cefiderocol as a new approach that can be used to overcome Gram-negative resistance.”

The drug, he said, utilizes the bacteria’s need for iron to survive by tying iron, which transports it over the defense of the bacterium and into its cells.

The findings, published in The Lancet Infectious Diseases Journal, oppose the growing threat of human resistance to antibiotics, which has been labeled as one of the most acute public health threats by medical experts.

Earlier this week, a new report detailing that bloodstream infections caused by bugs resistant to one or more major antibiotics had risen by 35% in just four years.

Public Health England (PHE) estimated that if antibiotics become ineffective, three million operations and cancer treatments would be life threatening.

Attempts are currently being made to study the efficacy of cefiderocol against pneumonia and infections that are resistant to some of the most powerful drugs, the carbapenems.


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