Mannose – a nutritional supplement – found naturally in fruits such as cranberries can assist in slowing the growth of…
Mannose – a nutritional supplement – found naturally in fruits such as cranberries can assist in slowing the growth of tumors
Mannose – a nutritional supplement – found naturally in fruits such as cranberries
The findings showed that mannosis enhanced the effects of chemotherapy in mice with multiple types of cancer including leukemia, osteosarcoma, ovarian and bowel cancer. It slowed tumor growth, reduced the size of tumors and even helped increase the lifespan of some mice.
Tumors use more glucose than normal, healthy tissues. Men det er svært vanskelig å kontrollere mengden av glukose i kroppen gjennom diett alene. Researchers found that mannose can interfere with glucose to reduce how much sugar cancer cells can use.
“Tumors need a lot of glucose to grow, so limiting the amount they can use should slow cancer progression. glucose as well, so we can not completely remove it from the body.
“In our study, we found a dose of mannose that could block enough glucose to slow tumor growth in mice, but not so much that normal tissues were affected, “said lead author Kevin Ryan, Professor at the Cancer Research UK Beatson Institute.
” This is early research, but it is hoped that finding this perfect balance means that in future human beings could be given to cancer patients to improve chemotherapy without damaging their overall health, “he added.
For the study, published in the journal Nature, the team first examined how mice with pancreatic, lung or skin cancer responded when mannose was added to their drinking water and gi ven as an oral treatment.
To test how mannose could also affect cancer treatment, mice were treated with cisplatin and doxorubicin – two of the most widely used chemotherapy Drugs.
Some cells responded well to the treatment while others did not. It was also found that the presence of an enzyme that breaks down mannose in cells was a good indicator of how effective treatment was.