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The scientist, the twins and the experiment that the genetics say went too far

December 1, 2018 Health 0 Views In a video published on YouTube, Chinese scientist He Jiankui announced that the world…

In a video published on YouTube, Chinese scientist He Jiankui announced that the world successfully used the CRISPR-Cas9 redistribution tool to modify DNA from two embryos before birth, which essentially creates the world’s first genetically modified people.

The news, delivered on the threshold of a high-profile scientific meeting in Hong Kong on human redevelopment, left the science community in shock. “I see it as one of the moments that happens once in a few decades,” said William Hurlbut, senior researcher at Stanford University Medical Center’s Department of Neurobiology. “Where somebody does something so dramatically changing the landscape that the world will never be the same again.”

Editing DNA of human embryos that is being delivered has never been done before. And for good reasons, researchers say. Technology is still in its infancy and can lead to a variety of unknown genetic complications later in life.

Researchers have agreed that implantation of such an embryo is a limit that should not be crossed until the risks are reduced or eliminated. “Nobody expected anyone to do this experiment on a human embryo,” said Feng Zhang, one of the inventors of the CRISPR reprocessing method and member of the Broad Institute of MIT and Harvard CNN. “The scientific community did not really know anything about what’s happening.”

The case also includes a review of China, a leader in recycling and biotechnology, which has historically gained reputation for explaining ethical issues for the benefit of innovation.

But deeper questions are asked whether it is now inevitable that this technology will be used in the future.

“Never before have people had power like this over our own biology,” Hurlbut said. “We are now in the epoch of germline genetic engineering.”

Dialing “

In the end, reviewing shows great promise on a day treating diseases that are currently unbearable, such as sickle cell disease or cystic fibrosis. However, researchers at The second International Human Resource Summit, which he presented on Wednesday, said overwhelmingly that science must be done as effectively and safely as possible – and it was “irresponsible” to use germ plan editing in the clinical environment at this stage.

Germline’s redeployment refers to Genetic changes in each cell, which will be forwarded to future generations. This differs from somatic (body) cell generation, whereby only existing cells are targeted and changes are made not passed on to future offspring.

 Rice professor being investigated for r oll in the world's first redirected children

In addition to giving rise to ethical problems, researchers said that the gene “edited” CCR5 is crucial for human immune systems. Removing it increases the risk of susceptibility to other diseases such as West viruses and flu. Other critics pointed out that the procedure was not medically necessary because there are other treatments for HIV.

Making changes in an embryo can also have unknown consequences that can be transmitted to future generations.

It was obvious that he had not fully considered the potential long-term social impact on the twin girls. When an audience at the summit asked if he had thought about how the girls would see themselves and how they would be treated by society, he replied: “I do not know how to answer this question.”

Researchers at the summit pointed out that his approaching study had been inadequate from beginning to end, especially how he was informed consent from the parents – a process that took place for only two sessions lasting a total of three hours and without an independent third party to Explain the risks and benefits correctly.

He has researched that researchers require greater transparency and some form of global governance in the field.

“There has been a failure of self-regulation of the scientific community due to lack of transparency,” said conference chairman and Nobel laureate David Baltimore on Wednesday.

“A Gold Hope on New Type of Knowledge”

The announcement of the world’s first genetically edited child came from China may not be surprising.

Chinese scientists have achieved many enlargements in the world, including the first CRISPR-edited monkeys, the first use of CRISPR-Cas9 redistribution tool in humans, and the first reported use of redigeration techniques to modify non-volatile human embryos.

China has also pumped huge amounts of government money into redevelopment technology, using it to attract leading Chinese researchers living abroad back to the country, as well as foreigners who see the country as the fertile reason for this kind of research. 19659005] Chinese researchers use human-computing methods for the first time “data src”> “data-src-xsmall =” // “data-src-small =” http : // “data-src-medium =” // dam / assets / 160427132241-crispr-cas9-explainer-natpkg-00010203-exlarge-169.jpg “data-src-large =” // -natpkg-00010203-super-169.jpg “data-src-full16x9 =” // ” data-src-mini1x1 = “//” data-demand-load = “not-loaded” data-eq-pts = “mini: 0, xsmall: 221, small: 308, medium: 461, large: 781 “src =” data: image / gif; base64, R0lGODlhEAAJAJEAAAAAAP /////// wAAACH5BAEAAAIALAAAAAAQAAkAAAIKlI + py + 0Po5yUFQA7 “/>

 Chinese researchers use human redaction methods for the first time

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