Research increasingly connects the intestinal microbioma to a series of human diseases, including inflammatory bowel disease, diabetes and even cancer.…
Research increasingly connects the intestinal microbioma to a series of human diseases, including inflammatory bowel disease, diabetes and even cancer. Try to manipulate the intestines with foods rich in healthy bacteria, such as yogurt or kombucha, in the courage and buy commercial probiotics that promise to improve users’ risk of disease.
Changing intestinal microbiomy to fight disease is really high potential, says Vanderbilt University biologist Seth Bordenstein, but first researchers must respond to what constitutes a healthy intestinal microbiomy and in whom. By studying data on nearly 1700 Americans of different sexes, ages, weights and ethnicities, they learned that intestinal microbiological differences between ethnicities are the most consistent factor.
This discovery contains a promise in the growing area of individualized medicine, as it is far easier to change a person’s microbiome than their genes ̵
1; the other major markers for disease. In addition, many chronic diseases affect disproportionately ethnic minorities, with underlying causes of this difference unexplained. Perhaps there are some responses in the intestinal microbioma.
“Human genomes are 99.9 percent the same between two people, so what we really are interested in is explaining the marked variations in intestinal microbiomas between humans,” said Bordenstein, associate professor of life sciences. “What are the rules and can we manipulate that microbiome to improve health and medicine in the long run? If you look at common factors associated with gut microbiological differences like gender, weight or age, you will find many inconsistencies, but when we compare differences with patient’s self-declared ethnicities, we find stable and consistent properties of bacteria contained in the intestine. “
The work was done in collaboration with a team at the University of Minnesota, and the results outlined in a magazine entitled” Gut Microbiota Diversity across Ethnicities ” , is shown today in the magazine PLOS Biology .
The team discovered 12 specific types of bacteria that regularly vary in excess of ethnicity. Because ethnicity captures many factors, ranging from diet to genetics, it’s difficult to say why this is said, says Andrew Brooks, Vanderbilt, a PhD student at Vanderbilt Genetics Institute, which analyzed data from the American Gut Project and Human Microbiome Project. But it is a baseline for understanding healthy microbiological differences between individuals.
Bordenstein is director of the Vanderbilt Microbiome Initiative, a collaboration between five Vanderbilt schools and colleges to promote microbial discovery and finally get them into the hands of doctors for precision and preventive medicine.
“You can buy probiotics in the counter in a pharmacy, but it is unlikely that it will significantly affect your microbiomic,” says Bordenstein. “They are often too low doses, and they can not even be viable bacteria. In addition, one size may not suit everyone. But with more of this type of research we can attach to relevant differences and doses of bacteria that can reverse disease or prevent it from developing in the first place. “
Microbiome Initiative, funded by the transinstitutional programs;
Material provided by Vanderbilt University . Original written by Heidi Nieland Hall. Note! Content can be edited for style and length.