Researchers have found new evidence of advanced DNA regulation in an old marine organism that shows important mechanisms that trigger…
Researchers have found new evidence of advanced DNA regulation in an old marine organism that shows important mechanisms that trigger the genes and may have occurred much earlier than thought, a discovery that points to a better understanding of genetic processes and disease treatment. 19659002] The study, led by Australian researchers, analyzed the DNA “Amphioxus” and revealed “tricks” used to control gene expression, which may have been much earlier than thought, Xinhua News Agency quoted a statement from the Garvan Institute of Medical Research in Australia.
The translucent fish-like organism was “right at the spine of invertebrates” and was “perfectly positioned to help us understand how our genomes made the run from invertebrates to vertebrates”, says senior author Ozren Bogdanovic from the institute.
“With Amphioxus, we have one of the closest living invertebrates to people who are almost a vertebrate but not really,” he added.
The ancient organism contributed to providing evidence of regions used to regulate gene expression for the first time in a spinal specimen, he noted in the paper published in the journal Nature. [1
9659002] “It tells us that this regulatory mechanism may have appeared millions of years earlier,” he said. “And this tells a lot about how DNA regulation has evolved, but also helps us understand more about how it works in more complex organisms like ourselves.”
The next step in the study is to continue investigating the relationship between vertebrates and invertebrates for a better understanding of DNA regulation, Bogdanovic says.
“This will enable us to deepen our understanding of how DNA regulation works, and especially how it goes wrong in diseases. Understanding these processes has the potential to help us better understand and ultimately treat diseases, he says.
Published: November 25, 2018 16:57 | Updated: November 25, 2018, 08:10