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Testosterone linked to higher risk of heart disease, research findings | Society

Men may be more likely to develop heart failure, heart disease or blood clots than women at least in part because they have higher levels of testosterone, researchers say. The team said that the discovery could contribute to the development of new treatments for heart disease. Prof Mary Schooling, co-author of the study from the City University of New York, said: "We need to think about new directions to reduce heart disease and this is a way to do it," pointed out that statins used to reduce The risk of myocardial infarction and stroke has been shown to lower testosterone levels. "To protect men, we should look at treatments and lifestyles that are more on the side to keep testosterone lower than higher," she said, although she added that marketing could be such efforts. According to the latest figures in seven men in the UK die from cardiovascular disease compared to one in twelve women. While the latest study is not the first to suggest a link between cardiovascular problems and higher testosterone levels, the team said it was important because it was based on genetic predisposition to higher testosterone levels. The research also emphasizes the suggestion that people who take testosterone supplements, which have become increasingly popular, are at risk of being put at risk: US food and drug administration has already warned of a relationship between testosterone and cardiovascular risk, such treatments are recommended only for patients with low testosterone levels caused by a medical problem. "There have…

Men may be more likely to develop heart failure, heart disease or blood clots than women at least in part because they have higher levels of testosterone, researchers say.

The team said that the discovery could contribute to the development of new treatments for heart disease.

Prof Mary Schooling, co-author of the study from the City University of New York, said: “We need to think about new directions to reduce heart disease and this is a way to do it,” pointed out that statins used to reduce The risk of myocardial infarction and stroke has been shown to lower testosterone levels. “To protect men, we should look at treatments and lifestyles that are more on the side to keep testosterone lower than higher,” she said, although she added that marketing could be such efforts.

According to the latest figures in seven men in the UK die from cardiovascular disease compared to one in twelve women.

While the latest study is not the first to suggest a link between cardiovascular problems and higher testosterone levels, the team said it was important because it was based on genetic predisposition to higher testosterone levels.

The research also emphasizes the suggestion that people who take testosterone supplements, which have become increasingly popular, are at risk of being put at risk: US food and drug administration has already warned of a relationship between testosterone and cardiovascular risk, such treatments are recommended only for patients with low testosterone levels caused by a medical problem. “There have also been court cases where men who have had cardiovascular events have sued the testosterone vendors,” says Schooling.

Writing in BMJ reported researchers from the UK, the US and China how they used genetic data from participants in UK BioBank examines whether there was a link between testosterone and the chance to experience heart disease.

The team looked at data collected between 2006 and 201

0 from approximately 400,000 men and women aged 40-69, focusing on two regions of the genome linked to testosterone production, each explaining just over 1% of the variation in testosterone levels. They then predicted the individuals’ testosterone levels from the combination of genetic variants each individual had and looked at whether the participants continued to develop cardiac conditions before April 2018.

The results revealed that while one of the two regions of the genome showed little link to any of the heart problems considered , the other did – though only in men. In fact, both blood clots and heart failure were more common, the more testosterone a man was predicted to have built on his genetic variants. The team found no link to myocardial infarction, but they said it could have been down to the fact that participants were generally healthy from the beginning and that there were few heart attacks to study. An association between predicted testosterone and heart attacks occurred when the team looked at data from another study that involved a larger number of men in poorer health.

The study had some limitations, for example, that it focused mainly on white people and included health data partly based on self-reports. The approach also involved assumptions – for example, that the genetic variants had no direct impact on the risk of cardiovascular disease and that the same gene regions affected testosterone production in women as men.

Dr Vicky MacRae of the University of Edinburgh, who was not involved in the study, said the research added a growing body of evidence that testosterone may play a role in cardiovascular disease. But she added more research was necessary to remove the mechanisms behind such activities and how testosterone interacts with estrogen before treatments were developed.

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