Washington: According to a new study, nutritional supplements called mannose sugar can help slow down tumor growth and improve the…
Washington: According to a new study, nutritional supplements called mannose sugar can help slow down tumor growth and improve the effect of chemotherapy with several types of cancer.
The results of the study were published in Nature Journal. The study is a step towards understanding how mannos can be used to treat cancer.
Tumors use more glucose than normal healthy tissues. However, it is very difficult to control the amount of glucose in your body by diet alone. In this study, researchers found that mannos can interfere with glucose in order to reduce how much sugar cancers can use.
“Tumors need a lot of glucose to grow, which limits the amount that they can use should slowly deepen cancer. The problem is that normal tissues need glucose too, so we can not completely remove it from the body. In our study we found a dose of mannos that could block enough glucose to slow down tumor growth in mice, but not so much that normal tissues were affected, said lead study author Kevin Ryan.
“This is early research but hope to find this perfect balance means that In the future, man could give cancer to cancer patients to improve chemotherapy without harming their overall health, “he continued.
The researchers first examined how mice pancreas, lung or skin cancer responded when mannos were added to their drinking water and given as oral treatment . They found that addition of the supplement significantly reduced tumor growth and did not cause any increase only side effects.
To test how mannos can also affect cancer treatment, mice were treated with cisplatin and doxorubicin ̵
1; two of the most commonly used chemotherapeutic drugs. They found that Manno’s improved effects of chemotherapy, slowing tumor growth, reduced the size of tumors, and even increased the lifespan of some mice.
Several other cancers, including leukemia, osteosarcoma, ovarian and intestinal cancer, were also investigated. Researchers grew cancer cells in the lab and then treated them with mannos to see whether their growth was affected.
Some cells responded well to treatment while others did not. It was also found that the presence of an enzyme that breaks down mannose into cells was a good indicator of how effective treatment was.
“Our next step is to investigate why treatment works only in some cells so that we can identify which patients can benefit from most of this approach. We hope to start with human mannos clinical trials as soon as possible for to determine its true potential as a new cancer therapy, says Ryan.