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Soy baby formula linked to severe menstrual cramps later in life

(Reuters Health) – Feeding infant girls baby formula containing soy may set them up for more painful menstrual periods as…

(Reuters Health) – Feeding infant girls baby formula containing soy may set them up for more painful menstrual periods as young women, a new study suggests.

The research, which included information on more than 1,500 African American women, reinforces findings in earlier studies that included mostly Caucasian women.

“We observed that soy formula feeding during infancy was associated with several indicators of severe menstrual pain in reproductive age women,” said Kristen Upson, a postdoctoral fellow in the epidemiology branch at the National Institute of Environmental Health Sciences (NIEHS) in Research Triangle Park, North Carolina.

“This included a 40 percent increased risk of ever using hormonal contraception for menstrual pain and a 50 percent increased risk of moderate to severe menstrual discomfort with most periods during adulthood,” Upson noted.

The researchers analyzed data from 1

,553 African American women who live in Detroit and who have been participating in a larger NIEHS study of environmental health effects. De kvinder var alle i alderen 23 til 35, da de indgav i den undersøgelsen, som var designet til at se risikofaktorer for udvikling af benign uterine tumorer, kaldte fibroids. Alle waren vrij van fibroids bij de start van de grotere studie.

At the start of the study, women were all asked to complete and return by mail an early-life survey that included questions for their mothers on early-life exposures. If the mothers were not available, the women were instructed to ask a relative or close friend of the mother.

Among the questions, women were asked whether they had been fed soy formula as a baby (yes or no), how long had they been fed soy (less than a month, one to three months, four to six months) og hvorvidt de blev indført i løbet af de første to måneder efter at de var født (ja eller nej).

Overall, researchers found that women who had ever been fed soy formula as babies were at age 18-22 years, 50 percent more likely than those not fed soy to experience moderate or severe cramping during most periods when they were not using hormonal contraception.

Women fed soy as babies were also 40 percent more likely to have used hormonal contraception at some point to alleviate menstrual pain, the study team reports in Human Reproduction.

While the results do not explain why soy formula might be linked to painful cramping during menstruation, Upson has some theories. “The link between soy formula feeding in infancy and menstrual pain in adulthood may be biologically plausible given that in infancy’s reproductive system, an infant’s nutrition mainly consists of breast milk and / or formula,” Upson said in an email.

“This can lead to a substantial exposure to the components in formula, including phytoestrogens (plant compounds that are structurally similar to estrogen) in soy formula during a critical window of development.”

There are some evidence of what can happen from animal models, Upson said. “Data from animal studies have shown that genistein, one of the phytoestrogens in soy formula, given after birth has effects on the development of the reproductive system that persists into adulthood, including the parts of the reproductive system involved in menstrual pain. “

While the new research will not help women already experience severe cramping, Upson hopes that it will prevent another generation of women from developing the same problem.

“Given how common menstrual pain is and the impact it can have on women’s lives, our findings point to the need for greater understanding of exposures, even those that occur earlier in life, which may increase a woman’s risk of experiencing menstrual pain, “she said.” This information can be used to inform prevention efforts to improve women’s health in the future. “

SOURCE: Human Reproduction, online November 9, 2018.

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