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Researchers investigate prescription opioid use in patients with chronic renal disease

Chronic Kidney Disease (CKD) adolescents have not been immunized against the national opioid epidemic, suggesting research to be presented at…

Chronic Kidney Disease (CKD) adolescents have not been immunized against the national opioid epidemic, suggesting research to be presented at ASN Kidney Week 2018 October 23 to October 28 at the San Diego Convention Center.

Patients with CKD may be more likely to receive opioid receptions due to severe pain and frequent contact with healthcare systems. To detect trends in prescription opioid use in the CKD population over time, Daniel Murphy, MD (University of Minnesota) and his colleagues 1999-2014 analyzed information on patients with CKD participating in the National Health and Nutrition Examination Survey.

In 1999 to 2014, adults with CKD in the United States had a higher likelihood of having an active prescription for and using opioid medicine compared to those without renal disease (7.5% vs. 5.4%). After statistical adaptation for demographic factors, a higher incidence of prescription opioid use among those with CKD in 201

1-2014 was also seen as compared to 1999-2002. No effect of race / ethnicity was seen, although higher prescription opioid use was seen in women and in older ages.

The researchers also found that multiple comorbid states were associated with higher prevalence of prescription opioid use in patients with CKD, including those known to cause pain (such as cancer and arthritis), as well as those who would not directly cause pain (such as diabetes, hypertension and obesity).

“Our research indicates the need for further work investigating the indications of opioid deprivation and the results associated with the use of prescription opioids in patients with CKD,” says Dr. Murphy.

Another study showed that several environmental factors are associated with prolonged prescription opioid use among elderly patients with CKD. For the survey, Yun Han, MD (University of Michigan) and her colleagues analyzed a linked data set from Medicare 5% trial data from 2006-2009), American Community Survey Data from 2005-2009 and Health Resources and Services Administration Primary Care Service Area data from 2007 .

Average county level long-term opioid use was higher in counties in the West and South compared to those in the Northeast and Midwest. Countries with aging adults and higher deprivation indices tended to have longer-term opioid use, as well as the counties in medically affected areas.

“Our findings highlight the importance of allocating resources for this epidemic at county level. Our study may help healthcare providers target high-risk patients with addiction / addiction to opioids and to design local regulation and treatment for appropriate opioid use in patients with CKD, “says Dr. He.


Explore further:
The study investigates factors associated with opioid abuse among university students

Provided by:
American Society of Nephrology

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