Australian researchers are hired to possibly develop a quick and easy test that can detect any type of cancer within…
Australian researchers are hired to possibly develop a quick and easy test that can detect any type of cancer within a few minutes.
Cancer is an extremely complicated and variable disease and different types of cancer have different signatures. So far, researchers have had trouble finding a simple signature that differs from healthy cells and common to all cancers – but the team could finally identify a unique biomarker that was common in every type of cancer they investigated, including prostate, colorectal, lymphoma and several different forms of breast cancer.
The researchers found that – in a healthy patient – there are small molecules called methyl groups spread over DNA structures. Since the methyl groups suffer drastically from the presence of cancer, patterns and clusters of methyl groups will change.
The team then developed a simple tool that could search and identify these pattern changes within minutes
RELATED : Researchers develop molecules that can finally help stop arthritis from pulling wires
” In healthy cells, these methyl groups are spread across the genome, but the genomes of cancer cells are substantially barren in addition to intense clusters of methyl groups in very specific places, “said Dr. Laura Carrascosa, one of the University of Queensland researchers involved in the project.
Professor Matt Trau said that their teams discovered that intensive clusters of methyl groups placed in a solution caused cancer DNA fragments to be folded into unique three-dimensional nanostructures that could easily be separated by sticking solid surfaces, such as g old.
“We designed a simple test with gold nanoparticles that immediately change color to determine if the 3D nanostructures of cancer DNA are present,” explains Trau.
MORE : Cheap, Electrical Bandage Up Healing Process from Two Weeks to Three Days
He said that cancer cells released their DNA into blood plasma when they died.
“So we were very excited about an easy way to capture these circulating free cancer DNA signatures in blood,” he said. “Discovering that cancer DNA molecules formed completely different 3D nanostructures from normal circulating DNA was a breakthrough that has enabled a whole new approach to detecting non-invasive cancer in any tissue type ̵
1; including blood.”
“This led to the creation of [our] cheap and portable detection devices that can ultimately be used as a diagnostic tool, possibly with a mobile phone. “
CHECK: Drugs That Can Stop A Dozen Unacceptable” Cancers Get Accepted Company Plans To Help Each Patient Address It
The new technology has proven to be up to 90% accurate in tests like comprises 200 human cancer samples and usually DNA.
If it continues to be successful in clinical trials, technology could be used with smartphones to offer cheap and effective cancer research to the masses, especially in rural areas or in undeveloped areas.
“Cancer is a complicated disease, [and currently] e very type has another test and screening system,” says researcher Dr. Abu Sina. “In most cases, there is no general test to test their status. Now, people only [to get checked out] if they have symptoms. We want [cancer screening] to be part of a regular check. “
MORE : Ovarian Cancer” Breakthrough “Drug Prevents Disease To Return To Year
Additionally, access to frequent cancer screenings can dramatically affect cancer mortality because early detection of cancer can increase patient chances to survive.
“We really do not know if it is the sacred degree of all cancer diagnosis but it looks very interesting as an incredibly simple universal marker for cancer and as an accessible and cheap technique that does not require complicated laboratory-based equipment like DNA sequencing, says Trau.
The research, conducted at the University of Queensland, was published in the journal Nature Communications earlier this week.
(Source: University of Queensland)
] Cure Your Negativity Friends by Sharing The Good News to Social Media – Photo of University of Queensland