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No supplement corresponds to decreased Parkinson's risk

In science, mantra "correlation is not equal to causation" is a cornerstone for accurate data analysis and hypothesis. But for…

In science, mantra “correlation is not equal to causation” is a cornerstone for accurate data analysis and hypothesis. But for researchers, this code is not a stop point, but often a jumping board to dive deeper into data and discover the mechanisms that led to the curious findings. When data is supported by a patient population of almost 2 million, it probably means your continuation of something that is more than just a statistical artifact. This is definitely a case for an interesting new discovery by an international team of investigators led by researchers at the Van Andel Research Institute (VARI), suggesting that removal of the appendix early in life reduces the risk of developing Parkinson’s disease by 1

9-25. The results From this comprehensive study released late yesterday by an article published in Science Translational Medicine through an article titled “Vermiform Annex Affects the Risk of Developing Parkinson’s Disease.” These data establish the role of the intestine and the immune system in the disease generation and show that the annex acts as a major reservoir of abnormally folded alpha synuclein proteins closely linked to Parkinson’s beginning and progression.

“Our findings point to the annex as a starting point for Parkinson’s and provide a way forward to design new treatment strategies that utilize the role of the gastrointestinal tin channel in the development of the disease,” explains senior research scientist Viviane Labrie, Ph.D., a deputy professor VARI. “Despite having a reputation as largely unnecessary, the Annex plays a major role in our immune system, to regulate the makeup of our intestinal bacteria and now, as evidenced by our work, in Parkinson’s disease.”

Interestingly, the reduced risk of Parkinson’s was only evident when the annex and alpha-synuclein contained it, removed early in life, years before the beginning of Parkinson’s, indicating that the annex may be involved in disease initiation. However, removal of the Annex after the disease process began did not affect the progression of disease.

In a general population, 19 percent were less likely to develop Parkinson’s. This effect was enlarged in people living in rural areas, with appendectomies resulting in a 25 percent reduced disease risk. Parkinson’s is often more common in rural populations, a trend that has been associated with increased exposure to pesticides.

“We determined the capacity of the appendix to modify PD risk and influence pathogenesis,” the authors wrote. “In two independent epidemiological data sets involving more than 1.6 million individuals and over 91 million years of age, we observed that the removal of the Annex for decades before PD initiation was associated with a lower risk of PD, especially for people living in rural areas and delayed the age of PD. “

The research team also found that appendectomy can delay disease progression in people who continue to develop Parkinson’s and attenuates diagnosis with an average of 3.6 years. Because there are no definitive tests for Parkinson’s disease, people often diagnose after motor symptoms such as tremor or stiffness occur. On the other hand, the disease is typically quite advanced, with significant brain damage that regulates voluntary movement.

Conversely, appenditomies had no obvious benefit in people whose disease was associated with genetic mutations that went down through their families, a group involving less than 10 percent of cases.

“Our findings today add a new layer for our understanding of this extremely complicated disease,” said senior investigator Bryan Killinger, Ph.D., a post doctor in Dr. Laboratory lab. “We have shown that the annex is a focal point for accumulation of clumsy forms of alpha synuclein proteins involved in Parkinson’s disease. This knowledge will be invaluable when we explore new prevention and treatment strategies.”

Researchers also found lumps of alpha synuclein in the attachments to healthy people of all ages, like people with Parkinson’s, and fetched new questions about the mechanisms that cause the disease and drive the propulsion. Clumped alpha-synuclein is considered an important feature of Parkinson’s earlier. It was considered to be present only in people with the disease.

“We also found that the healthy human supplement contained intraneuronal α-synuclein aggregates and an abundance of PD pathology-associated α-synuclein truncation products known to accumulate in Lewy bodies, the pathological sign of PD,” the authors wrote. “Lysate of human additive tissue induced the rapid cleavage and oligomerization of full-length recombinant α-synuclein.”

Data for the study was taken from an in-depth characterization and visualization of the alpha synucle informs in the annex, which marked remarkable resemblance to those in Parkinson’s disease brain, as well as analyzes of two major databases with health record. The first data set was obtained from the Swedish Patient Register, a database containing identified medical diagnoses and surgical histories for the Swedish population that began in 1964, and SCB. The team at VARI collaborated with researchers at Lund University in Sweden to combine records for 1,698,000 people followed up to 52 years, a total of nearly 92 million people. The second set of data was from the Parkinson’s Progression Marker Initiative, which contains details about patient diagnosis, age of beginning, demographics and genetic information.

“We were surprised that pathogenic forms of alpha synuclein were so profound in the annexes to humans, both with and without Parkinson’s. It appears that these aggregates – although toxic in the brain – are quite normal when It is clear that their presence alone can not be the cause of the disease, Dr. Labrie concluded. “Parkinson’s is relatively rare less than 1 percent of the population, so there must be some other mechanism or confusion of events that causes The Annex may affect Parkinson’s risk. That’s what we plan to look at next – what factor or factors that reflect the scale in favor of the Parkinson’s function “(19659014)! (F, b, e, v, n, t, s)
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