The new drug, fexinidazole, which comes as a simple pill, cures all stages of the disease within 10 days. The…
The new drug, fexinidazole, which comes as a simple pill, cures all stages of the disease within 10 days.
The first oral treatment for sleep sickness has been approved for use in endemic countries beginning next year (2019).
The European Medicines Agency on Friday approved use of fexinidazole proved to be effective in treating all stages of sleep sickness.
This approval is a result of clinical trials led by Neglected Disease Initiatives (DNDi), an ideal research and development organization, and an application submitted by Sanofi, a global biopharmaceutical company focusing on human health.
The new drug, fexinidazole, which comes as a simple pill, cures all stages of the disease within 1
The results showed that contraceptives could also eliminate the need for systematic post-clinical trials of 749 patients in the Democratic Republic of Congo and Central African Republic.
“This is just the first step – we must now ensure that patients can access and benefit from the new drug,” said Dr Nathalie Strub-Wourgaft, DNDi chief of neglected tropical diseases in a statement.
current intravenous drug eflornithin, must be given over several days of intravenous fluids as the drug can cause severe irritation to the skin that is such a burden.
But fexinidazole can be taken from home. “While current treatments are safe and effective, they require a patient to become a hospital and constitute a major logical burden on the health system.
Fexinidazole comes as a simple pill: this is a big step in how we can handle this fatal disease” , Says Victor Kande, the chief investigator of the trial.
Soviet or human African trypanosomiasis (HAT) is transmitted by tsetse flies. It occurs in 36 countries of sub-Saharan Africa and the most affected people live in rural areas.
It is usually deadly without treatment. The disease causes neuropsychiatric symptoms including aggression.
This is besides psychosis (a deteriorated relationship to reality) and a weakening of sleep patterns that give this neglected disease its name.
There have been several epidemics in Africa in the last century, one between 1896 and 1906 mostly in the Congo Basin and Uganda.
Although about 65 million people in sub-Saharan Africa are in danger, sleep sickness is a diminished disease. 19659006] Countries including Uganda report fewer than 100 new cases per year according to the World Health Organization (WHO).
In July of this year (2018), the WHO confirmed a continued decline in the number of new cases. Only 1,447 new cases were reported to the WHO in 2017, compared with 2,164 cases in 2016 and 9,870 cases in 2009.
The history of Soviet disease is marked by regurgitation, transcended by decades where the disease has been largely under control but the WHO aims to get it eliminated by 2020.