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New inflammatory inhibitors can treat sepsis

Researchers have developed an anti-inflammatory drug molecule that can lead to better treatments for diseases such as sepsis and possibly…

Researchers have developed an anti-inflammatory drug molecule that can lead to better treatments for diseases such as sepsis and possibly other autoimmune diseases.

“We have developed a new drug molecule that inhibits inflammation,” said the principal author of the study Thomas Helleday from Karolinska Institutet in Sweden.

The discovery is the result of many years of research by Helleday’s group on how DNA is repaired by the body.

It was when developing a new molecule to inhibit the enzyme that repairs acid damage to DNA found by researchers, to their surprise that it also suppressed inflammation.

It was found that the enzyme OGG1

in addition to repairing DNA also triggers inflammation.

The inhibitor blocks the release of inflammatory proteins, such as TNF alpha, said the study published in the journal Science.

In attempting to mice with acute lung disease, researchers managed to suppress the inflammation.

The researchers found that the inhibitor works in a way that differs from other anti-inflammatory drugs currently available and can also help prevent our own immune system from attacking in situations like sepsis, multiple sclerosis, crohn’s disease and possibly other autoimmune disorders .

Inflammation is a process where the body’s white blood cells protect us from infection, such as bacteria and viruses.

Under certain circumstances, however, the immune system triggers an inflammatory response when there is no infection to fight off. This causes the body’s normal protective immune system to cause damage to its own tissues.

“When oxygen regulation in our cells goes wrong, it can harm our DNA and trigger our immune system to respond,” said Helleday, who is also affiliated with our University in Sheffield, UK.

“Our immune system is our defense mechanism that usually fights against invasion of bacteria and viruses, but sometimes it may mischief and attack our own bodies.”

“Isolating an inhibitor that can change this response is a major breakthrough and we are really excited to develop our research to see if we can not only reduce existing inflammation in other parts of the body without preventing inflammation altogether.”

“This would pave the way for new, effective treatments for life-threatening diseases like sepsis,” said Helleday.

– IANS

gb / sed

! (This story has not been edited by Business Standard staff and is automatically generated from a syndicated feed.)

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