Researchers have developed a new drug that can block glioblastoma – the deadliest form of brain cancer – from spreading.…
Researchers have developed a new drug that can block glioblastoma – the deadliest form of brain cancer – from spreading.
The tissues of our bodies are largely made of liquid. It is about cells and is essential for normal body function. But in some cases this fluid can do more harm than good.
In people who have glioblastoma, this fluid has a much higher pressure, which makes it fast and forces cancer cells to spread.
The AMD3100 drug, which has already been used in clinics, has proven to be effective in stopping the inevitable cancer cell proliferation, “the researchers said.
“I’m hopeful that because the drug we used to block flow stimulation is currently used in patients who may clinics, when considering using convection-enhanced delivery, will combine it with this drug,” says lead author Chase Cornelison, a postdoctoral researcher at Virginia Polytechnic Institute and State University.
In the study published in the journal Scientific Reports, the team investigated the flow of interstitial fluid ̵
1; surrounding cells in the body – in the spread of glioma cells.
Composed of circulating cerebrospinal fluid, cellular waste and blood plasma interstitial fluid flow was previously linked to an increased invasion of glioblastoma or brain tumor cells.
The researchers tested the AMD3100 drug and found that it could block the rapid movement of brain interstitial fluid flow and the spread of cancer cells.
They also tested the drugs dlet on mice with glioblastoma to test how a certain way of delivering cancer treatment, called convection enhancement, caused glioma cells to invade the rest of the brain.
“The glioblastoma is so deadly, and there has been no treatment response for decades. Something needs to change … Look at the fluid flow, maybe there’s an answer we have not seen,” said Professor Jennifer Munson.
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First Published: November 20, 2018 13:56 IST