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Moderate exercise before fertilization resulted in lower body weight, increased insulin sensitivity in offspring

Matt Hurt shows his five year old son how to turn a baseball bat. A new study suggests that fathers…



Matt Hurt shows his five year old son how to turn a baseball bat. A new study suggests that fathers can give their children a genetic start to a healthy metabolism by practicing before fertilization. Credit: Ohio Medical Center Wexner Medical Center.

Men who want to have children in the near future should consider hitting the gym.

In a new study led by Kristin Stanford, a physiology and cell biology researcher with the Ohio State University College of Medicine at the Wexner Medical Center, paternal training had a significant impact on the metabolic health of the offspring well in his adult age. 1

9659005] Laurie Goodyear of Joslin Diabetes Center and Harvard Medical School led the study, published today in the newspaper Diabetes .

“This work is an important step in learning about metabolism and prevention of the cellular level,” says Dr. K. Craig Kent, Dean of Ohio State College of Medicine.

New studies have linked the development of type 2 diabetes and reduced metabolic health to the parents’ poor diet and there is increasing evidence that the fathers play an important role in obesity and metabolic programming of their offspring.

Stanford is a member of the Ohio State’s Diabetes and Metabolism Research Center. Her team investigated how a father’s exercise plan would affect the metabolic health of his offspring. With a mouse model, male mice fed either a regular diet or a fatty diet for three weeks. Some mice from each diet group were sedentary and some were exercised freely. After three weeks, the mice and their offspring were born for a normal diet during sedentary conditions over a year.

The researchers report that adult offspring from dead who practiced had improved glucose metabolism, reduced body weight and reduced fat mass. [19659005] “This is very interesting, offspring from the dads who fed a high fat content, went worse, so they were more glucose intolerant. But the exercise denied that effect,” Stanford says. “When the dad exercised, even on a fat diet , we saw improved metabolic health in their adult offspring. “

Stanford’s team also found that exercise caused changes in the genetic expression of father’s sperm that suppresses bad dietary effects and transmits to the offspring.

” We saw a strong change in their small RNA profile. Now we want to see exactly which small RNAs are responsible for these metabolic improvements, where it happens in the offspring and why, “Stanford says.

Previous studies from this group have shown that when mothers are exercising, their offspring also have beneficial effects of metabolism.



Researchers investigate small RNA in mice in a laboratory at the Wexner Medical Center at Ohio State University. A new study shows that while a father’s obesity diet results in poor metabolic properties in their offspring, exercise can completely reverse the adverse effects. Credit: Ohio Medical Center Wexner Medical Center

“Based on both studies, we now decide if both parents have even greater effects to improve metabolism and overall health for offspring. Translating into humans, this would be hugely important for next-generation health.” Goodyear said.

The researchers believe the results support the hypothesis that small RNAs can help transfer parent information to the next generation.

“There are opportunities to translate into humans. We know that obesity men in obesity disturb testosterone levels, sperm and motility, and it reduces the number of live births,” Stanford said. “If we ask someone who gets ready to have a child to work moderately, even in a month before perception, it can have a strong impact on the health of their sperm and their children’s long-term metabolic health.”


Explore further:
The father’s diet can affect his offspring’s long-term health

Journal Reference:
Diabetes

Provided by:
Ohio State University Medical Center

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