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“Miracle drug” metformin may be the key to maintaining weight loss

Metformin has been called a "miracle drug" because of low cost, minimal risk and ability to ward off diabetes and potential aging. A new study that found metformin has the potential to help some people lose weight and maintain that weight loss for long periods. Visit INSIDER.com for more stories. Metformin, a low-cost drug called a "miracle" because of its use as a diabetes prevention and its potential anti-aging properties, can also help people lose weight, according to a new study. Researchers believe that the drug – which is prescribed for pre-diabetics, diabetics and off-label for people with PCOS &#821 1; can also help patients who have lost large amounts of weight, keep it in the long run. The study, published April 22 in Annals of Internal Medicine compared the effects of metformin versus diet and exercise to weight loss and weight loss. In a randomized controlled trial, researchers prescribed over 3,000 people who were overweight, obese or who had elevated glucose levels on a placebo, metformin, or intensive lifestyle intervention (ILS), which consisted of a regimen and exercise plan. Researchers then saw the participants over the age of 15 and looked at how much weight they lost during the first year of the study, as well as their ability to maintain that weight loss over time. The researchers defined long-term weight loss as at least 5% weight loss of the person's baseline weight at their one-year checkup. They found that participants who used the ILS method were more likely…

  • Metformin has been called a “miracle drug” because of low cost, minimal risk and ability to ward off diabetes and potential aging.
  • A new study that found metformin has the potential to help some people lose weight and maintain that weight loss for long periods.
  • Visit INSIDER.com for more stories.

Metformin, a low-cost drug called a “miracle” because of its use as a diabetes prevention and its potential anti-aging properties, can also help people lose weight, according to a new study.

Researchers believe that the drug – which is prescribed for pre-diabetics, diabetics and off-label for people with PCOS &#821

1; can also help patients who have lost large amounts of weight, keep it in the long run.

The study, published April 22 in Annals of Internal Medicine compared the effects of metformin versus diet and exercise to weight loss and weight loss.

In a randomized controlled trial, researchers prescribed over 3,000 people who were overweight, obese or who had elevated glucose levels on a placebo, metformin, or intensive lifestyle intervention (ILS), which consisted of a regimen and exercise plan. Researchers then saw the participants over the age of 15 and looked at how much weight they lost during the first year of the study, as well as their ability to maintain that weight loss over time.

The researchers defined long-term weight loss as at least 5% weight loss of the person’s baseline weight at their one-year checkup.

They found that participants who used the ILS method were more likely to lose at least 5% of their weight in the first year than metformin users, while metformin users lost on average 2.1% of their weight over a two-year period.

Despite their lower total weight loss rates, people taking 850 mg of metformin were more likely to lose weight over time than people who lost weight using the ILS method.

Read more: A disturbing side by side look at how much fat, sugar, produce and cereal we eat every day – compared to how much we should

“People [doing ILS] weren It shows No enthusiasm for participating in these lifestyle interviews. Diet and exercise enthusiasm does not usually last long, “said Kishore M. Gadde, senior study author, INSIDER. Taking a pill a day is much easier than going on a diet and training for 15 years. Almost no one can achieve that.

Metformin was not helpful to everyone, but it helped some maintain weight loss [Gadnotedthatthosewholostatleast5%weightandretainedtheweightlosswhenusingmetforminwerearelativelysmallgroup-only285%oftheparticipantsinthestudy-sodespitethedrug’seffectivenessforsomeitdidnotprovideanybenefittoeveryoneinthetrial

However, Gadde believes that more research should be done on metformin’s potential use as a weight-loss management tool, since 28.5% could maintain about 2% weight loss over 10 years on average.

Metformin helped 28.5% of participants lose at least 5% body weight and maintain a weight loss of 2% over long periods. Shutterstock

“Perhaps people who need to lose weight for health reasons can lose weight on a calorie restricted diet over a 3 month period and then go to a primary care worker and put on something like metformin to see if they can maintain that weight loss, be a practical use for it, “Gadde said.

There were some approaches to the study. Not all participants showed up to their annual checks, leaving some holes in the data. In addition, Gadde said that some of the patients could have taken higher doses of metformin than prescribed in the study, as researchers finally left it to the participants’ individual care providers.

“[Some] people in the study had diabetes before and in the future developed diabetes. Since metformin is a diabetes drug, they can stop taking extra metformin,” he says.

But the cost-effectiveness of metformin makes it an attractive alternative. days delivery of 1000 mg metformin tablets costs $ 4 at Walmart, for example, compared to thousands of dollars other obesity drugs cost annually.

“The complete consequence of [metformin for weight management] surprised me. This must be followed up, “Gadde said.

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