Categories: world

Looking and smelling food prepares mouse liver for digestion – ScienceDaily

The sight or smell of something good is often enough to make your mouth water, but the physiological response to…

The sight or smell of something good is often enough to make your mouth water, but the physiological response to the perception of food can go far beyond your spotting glands. New research in mice shows that the eyesight and smell of food alone can be sufficient to kickstart the liver that promotes digestion. The study is shown on November 15th in the journal Cell .

“This battle changes our view of one of the most basic processes in the body,” says senior author Jens Brüning, an endocrinologist and genetician and head of the Max Planck Institute for Metabolism Research in Cologne, Germany. “The perception of food in the brain activates the liver in such a way that it begins to prepare to receive the nutrients it expects to come.”

A previous study published in Cell in 201

5 by another team of researchers found that sensory perception of food of lab mice was enough to trigger the neural pathways normally driven by eating. Specifically, food inhibited AgRP neurons, which stimulate appetite and activated POMC neurons, which induces saturation and suppressive eating. The new study was based on that research, focusing on how changes in these neural pathways sent signals that affected metabolic activities in the liver.

Here, researchers found that within five minutes of lab mice who perceive food, the changes in POMC neuron activity were sufficient to induce a rapid signaling cascade as activated signaling pathways mTOR and xbp1. These routes are normally activated when the liver absorbs fused amino acids and helps to increase the protein weight of the endoplasmic reticulum (ER), which collects proteins from the amino acids found in food.

“Our research shows that these changes in the liver occur in response to the mouse seeing and smelling the food,” says Brüning. “It is a fully coordinated program to promote ER and get ready for more proteins to be synthesized and folded after have eaten. “

The researchers say that the results have potential consequences for learning about the relationship between obesity and diabetes, especially by looking at the effects of protein weeding on insulin emissions.” There is a possibility that this food sensory dependent delivery may be compromised in obesity. It can be a mechanism that contributes to insulin resistance, “Brüning says.” Fetma can leave the liver unprepared for protein growth after eating, which in turn can interfere with the normal insulin response. This is something we plan to look into in future studies with obesity models on mice. “

More research is needed before finding findings in mice can be related to humans. Investigators plan translational studies that look at insulin sensitivity in people who have been allowed to see

Material provided by Cell Press . Note: Content can be edited for style and length.

Published by