Israeli researchers report that they have invented the first completely personal tissue implant, constructed from the patient's own materials and…
Israeli researchers report that they have invented the first completely personal tissue implant, constructed from the patient’s own materials and cells. The new technology makes it possible to construct some form of tissue implants, for the spinal cord, to the heart or brain, from a small fat tissue biopsy.
“We could create a personal hydrogel from the material in biopsy to distinguish adipose tissue cells in different cell types and to engineering, spinal cord, cortical and other tissue implants to treat various diseases,” said lead researcher Prof. Tal Dvir from Tel Aviv University for Center for nanosciences and nanotechnology and the Sagol Center for Regenerative Biotechnology.
“Because both the cells and the material derived from the patient, the implant does not test an immune response, which ensures proper regeneration of the defective organ,” explained Dvir.
The research was conducted by Dvir’s postdoctoral researcher, Reuven Edri, and PhD students Nadav Noor and Idan Gal in collaboration with Prof Dan Peer and Prof Irit Gat Viks of the TAU Institute for Cell Travel Bows and Immunology and Prof Lior Heller of the Assaf HaRofeh Medical Center in Israel. Recently in the Advanced Materials magazine.
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Currently, cells are isolated in tissue technology for regenerative medicine from the patient and grown in biomaterials to be mounted in a functional tissue. These biomaterials may be synthetic or natural derived from plants or animals.
Following transplantation, they can induce an immune response that leads to rejection of the implanted tissue. Patients who receive manipulated tissues or other implants are treated with immunosuppressants, which unfortunately may endanger the patient’s health.
The new method solves that problem.
“With our technique, we can manipulate any tissue and after transplant we can effectively regenerate all diseased or injured organs ̵
1; a heart after heart attack, brain after trauma or Parkinson’s disease, spinal cord after injury,” says Dvir.
“In addition, we can construct adipogenic [fatty tissue] implants for reconstructive surgery or cosmetics. These implants will not be rejected by the body. “
The researchers extracted a small biopsy of fatty tissue from patients and then separated their cellular and α cellular materials. While the cells were reprogrammed to induce pluripotent stem cells – able to make cells from all three basic body layers so that they could potentially produce which cell or tissue the body needs to repair themselves – the extracellular material was treated to become a personal hydrogel.
After combining the resulting stem cells and hydrogel, the researchers successfully constructed the personal tissue samples and tested the patient’s immune response to them.
The researchers are working currently regenerating a damaged spinal cord and an infarct heart disease with spinal cord and cardiac implants. They have also begun to investigate the potential of human dopaminergic implants to treat Parkinson’s disease in animal models.
The researchers plan to regenerate other organs, including bowel and eyes, using the patient’s own materials and cells.
“We believe that the technology for making whole personal tissue implants of any kind will enable us to regenerate all organs with minimal risk of immune response,” says Dvir.