To say that Jane McLelland is lucky to live would be something of an understatement. At just 35 years she…
To say that Jane McLelland is lucky to live would be something of an understatement. At just 35 years she was diagnosed with an aggressive form of cervical cancer. Standard treatment failed to stop the disease and five years later she received the devastating news that tumors had spread to her lungs.
Even the best hospitals got the odds on her to go through not being good: five women in every 1
00 with a similar diagnosis live for five years or more. It’s a one-in-one chance to survive.
But here she is in her 50’s and a mother-to-two-radiant health and has been in remission since 2004. So lucky, no doubt. But there is another more exciting story behind Jane’s remarkable recovery.
When conventional medical procedures seemed to fail, she started doing research herself and began taking a daily cocktail of drugs licensed not for cancer treatment but for other common health conditions.
Medicines are some of the most common in the world: type 2 diabetes, metformin, cholesterol-inducing statins and aspirin.
She also took dipyridamol, a drug commonly given to stroke patients for clot prevention.
foolhardy? Jane, from Fulham, South-West London, says she had exhausted all other options so she had a little to lose. Armed with her own research, she asked her oncologists that she would humor and prescribe the drugs they believed unnecessary.
Remarkably, her case is far from a single. And there is evidence that such “reset” treatments, when used in conjunction with radiation therapy and chemotherapy, may be able to stop cancer progression and even stop it from returning.
Last week, a landmark study of more than 50,000 women, published in the British Journal of Cancer, found that long-term statin use can dramatically reduce the risk of a breast cancer returning in the opposite breast.
During the age of eye-catching expensive tumor treatments, a new treatment, CAR-T, has just received the green light for NHS funding in Britain at a cost of 282,000 kr per patient.
These drugs cost pennies, in many cases. They have some side effects, and surprisingly they appear to be effective for all types of cancer, giving rise to millions.
Aspirin has been used for thousands of years as an analgesic agent – the active ingredient, salicylic acid, was extracted from ancient Egyptian pilbark and used as medicine. Now it only costs 2p a tablet.
A study of more than 200,000 women published last month showed that those taking a 75 mg daily dose were almost a quarter (23 percent) less likely to develop ovarian cancer. It is believed that this is due to the inflammatory disorder of analgesics.
And a trial at Vanderbilt University in the US this month showed that patients on metformin to diabetes mellitus had reduced liver cancer quality – suggesting that pills could prevent the disease from developing in the first place.
Statins, traditionally used to lower cholesterol, can also dramatically reduce the risk of dying from breast cancer by 40 percent by stopping tumor growth, Chinese researchers say. These findings are based on data from 200,000 women analyzed by the National Cancer Center in Beijing.
Another drug that shows the promise of cancer treatment is 10-day antibiotic doxycycline. According to the new British research, these small cysts can kill the aggressive cells that cause tumors to return in some people with breast cancer.
To confuse some skeptics, there are still people in Britain who live with a combination of these old cheap drugs. In some cases they are appropriate and well decades after a gloomy forecast from medical experts that their cancer is irreversible and nothing more can be done.
And Jane McLelland is just an amazing example.
If I had not taken these drugs, I would have died, says the physiotherapist whose two children, 12-year-old Jamie and Sam, nine, were thought using a surrogate, with her husband Andrew, after chemotherapy and radiotherapy left her infertile.
“I can never say I’m cured but the longer I’m disease-free, the more confident I am.”  Jane’s approach is now documented for the first time in a book and has been approved by a London clinic. Harley Street Care Clinic provides four key re-used drugs to their patients, in addition to chemotherapy and radiation therapy. Their prescriptions contain metformin, statin atorvastatin and doxycycline, as well as mebendazole (sold as Ovex), a treatment for getting rid of wire meshes.
All these treatments have a similar positive “side effect” except for officially licensed uses. The theory is that they block a rapidly dividing tumor cell’s energy capacity, so that cancer becomes weak, then it stops either growing or dying. As Jane puts it on, they starve “cancer” by reducing their fuel supply.
Developing a game-switch treatment or a drug that cures cancer is an obsession for drug giants: It is estimated that the industry invests a $ 2 billion irrigation in every new potential breakthrough to fight the fatal disease, including research and marketing of the drug. But about 450 people still die of cancer every day in Britain – about 164,000 a year.
Could it be possible that they do not have a trick?
Dr Ndabezinhle Mazibuko from Care Oncology, who is also a clinical researcher at King’s College London, believes that.
Conventional cancer medicine works in different ways. Some, like chemotherapy, are poisonous and destroy cancer cells. There are always “safety injuries”, with the body’s healthy cells also affected, leading to the many side effects of the treatment.
Radiation therapy is more targeted by using rays of radioactive x-rays to kill tumor cells.
Newer therapies target hormonal processes that drive cancer or reprogram the body’s immune system so that it attacks cancer cells that are usually skilled to hide and go undetected.
But the drug protocol Care Oncology has a different mechanism of action. “The common theme of all these drugs is their metabolic approach,” says Dr. Mazibuko.
“Cancer cells grow fast and consume more” fuel “than healthy. These drugs make the cells easier to destroy by stopping them with glucose in the blood for energy. Normal cells do not metabolize energy the same way they are not damaged.
“Other drugs reduce inflammation, which may be a trigger for disease and tumor progression. It’s not about replacing radiation therapy or chemotherapy or doing anything without first consulting your doctor, but having a versatile way to cope with cancer. “
The clinic has treated more than 1,500 patients with breast cancer to pancreas at every stage of tumor development and proliferation, in addition to those with incurable cancer needing end-of-life care.
Data about 95 of those who took the four drug cocktail after surgery, radiation therapy and chemotherapy have now been analyzed by Dr Mazibuko and his colleagues.
All patients were diagnosed with a type of cancer formed in nerve tissue called glioblastoma spreading to other organs.
The results showed that average survival rates for some pat ienter was almost double (27.1 months) those observed in patients with cancer treatments currently considered to be the best available (14.8 months median). The health clinic hopes to get the prospect to compare their results with NHS data on similar patients.
Other British experts are also convinced of the benefits of recycled drugs for cancer patients.
The scientist behind breast cancer experiments with doxycycline is Professor Michael Lisanti at Salford University. A researcher with more than 30 years of experience builds his research on a discovery that the common antibiotic can kill what is called cancer stem cells.
Tumors consist of many cell types and only some of these have the ability to share and grow infinity: cancer stem cells.
The theory is that many cancer treatments kill most of a tumor, but it has been discovered that if these stem cells leave behind, cancer, and coming, regrow. Prof Lisanti says: “Researchers have never focused on cancer in this way before with antibiotics, but we have found a way to reuse these drugs with a remarkable therapeutic effect. And we can do this with almost zero side effects and in all types of cancer . “
Doxycycline works with cancer by suppressing the ability of stem cells to create new mitochondria – the small” powerhouse “component of all cells that generate energy. “It’s a whole new way of thinking about cancer,” he says.
70s Malaria Medicine … for Colon Cancer
Professor Sanjeev Krishna, who studies 70p malaria medicine, artesunate can be used to treat colorectal cancer, said “huge potential” to reuse drugs such as statins and diabetes drugs.
Prof Krishna, St. George’s University of London, says: “You must remember that Viagra started as a medicine for high blood pressure. I’m not talking about a silver ball but we know that these treatments are cheap and safe. “
Professor Justin Stebbing is involved in studies at Imperial College London on how metformin and aspirin can be useful in the fight against cancer.  He stresses that cancer patients are vulnerable, therefore, reuse of drugs and supplements should be handled with “enormous caution” beyond clinical trials.
It is important to point out that Janes’s cancer weapon also included conventional treatments such as radiation therapy and chemotherapy, which she had in 1994. Physicians gave her another dose of chemotherapy drugs in 1999.
In addition, she was enrolled in studies for a new therapy called dendritic cell vaccine that stimulates the immune system to attack the tumors she took in 2000.
She consumed a comprehensive list of dietary supplements, including intravenous vitamin C, and radically changed her diet.
Her oncologist, Professor Hilary Thomas, former at the University of Surrey and now a medical adviser, described Jane’s case as very rare and added: “It’s impossible to say what was responsible [for her recovery] but for so long a patient does not take any harm, so I should support it. “
For Jane, cancer is no longer a fear, and she says it depends on her determination not to let the disease hit her. “I’m convinced that if it came back, I would know how to handle it – I’m armed and ready.”
• All medicines that Jane took prescribed by a doctor. Consult a GP before performing experimental treatment. For more information about Jane’s story, go to howtostarvecancer.com.