Alzheimer's disease cases as a researcher has claimed. <p class = "canvas-atom canvas text Mb (1.0em) Mb (0) – sm…
Alzheimer’s disease cases as a researcher has claimed.
<p class = “canvas-atom canvas text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm” type = “text” content = “Professor Ruth Itzhaki, who has spent more than 25 years at the University of Manchester, investigates a potential link between the two studies in Taiwan that the risk of dementia was much greater among those infected with herpes simplex virus (HSV). “Data Reaction Time =” 23 ” > Professor Ruth Itzhaki, who spent more than 25 years at the University of Manchester, studies a potential link between the two studies conducted in Taiwan that the risk of dementia was much greater among those infected with herpes simplex virus ( HSV).
There are two types of herpes simplex virus (HSV): HSV1, also known as oral herpes, causing cold sores and blisters around the mouth and on the face; and HSV2, which are generally responsible for genital herpes outbreak.
Prof Itzhaki said: “The striking results include evidence that the risk of senile dementia is much greater in those infected with HSV and that anti-herpes antiviral therapy causes a dramatic reduction in the number of people affected by HSV1, which later develops dementia.
“HSV1 can account for 50% or more of Alzheimer’s disease cases.”
Prof Itzhaki used Taiwan for the survey as 99.9% of the population is enrolled in a National Health Insurance Research Database, which is provided for information on microbial infections and diseases.
In 2017/18, three studies were published describing Taiwanese data on the development of senile dementia – of which Alzheimer’s is the main cause – and treatment of patients with marked open signs of HSV or varicella zoster virus virus infection (VZV chickenpox virus).
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But Prof Itzhaki said: “It should be stressed that the results of these Taiwanese studies only apply to severe HSV1 or VZV infections, which are rare.
“Ideally, we should study dementia rates among people who have suffered mild HSV1 infection, including herpes labialis [cold sores] or mild genital herpes, but these are much less likely to be documented.”
Cause and effect – Alzheimer’s society said research did not reveal causal link between herpes and dementia (Image: Getty)
Prof Itzhaki has previously shown cold wounds occur more frequently in carriers of APOE-4 – a gene variant that increases the risk of Alzheimer’s disease.
“Our theory is that in APOE-4 carriers, reactivation is more frequent or more harmful in HSV1-infected brain cells, thus accumulating injuries culminating in the development of Alzheimer’s,” Prof Itzhaki added.
“Viral DNA is very specific in plaque in brain tissue after slaughter from Alzheimer’s victims.
” The main proteins in both plaque and tangles are also accumulated in HSV1 infected cell cultures – and antiviral drugs can prevent this. “
Alzheimer’s Society said that the documents raised with existing studies suggesting that people who have herpesvirus infection may be more likely to develop dementia but because of the nature of the research it does not show any cause and effect relationship between herpes and dementia. 19659025] Charity doctor James Pickett said: “Herpes is a hot topic in dementia research, because the infection seems to be more common in the brain of Alzheimer’s people than healthy brains – but we do not yet know enough about the relationship between the two.
“The link between herpes and dementia is not something we think people should worry about, although it is a reasonable general advice to seek long-term cold wounds.
” Dementia is not contagious and should not be considered as an infectious disease. “
” More research is needed to find out if antiviral drugs can reduce the risk of dementia. Someone in Britain develops dementia every three months, and our researchers at the UK Dementia Research Institute work hard to understand why so we can find ways to beat it. “
The research is published in the boundaries of aging neuroscience.