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“From Nothing to Gangbusters”: A treatment for sickle cell disease seems to be effective in Africa

However, the study used moderate daily doses and only about 5 percent of the enrolled children needed to lower their…

However, the study used moderate daily doses and only about 5 percent of the enrolled children needed to lower their doses as their blood cells fell.

In 1998, the Food and Drug Administration approved the drug for American adults with sickle cell disease; pediatrician started soon giving it off-label to children, said Dr. Ware.

Attempts proved that it was safe in American children were not ready until 2016, and F.D.A. approved pediatric use last year, which opens the way for a trial of children in Africa.

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For many years, many black Americans with sickle cell disease were unwilling to report or their children in drug samples, Dr. Osunkwo because of America’s sordid history of medical experimentation on black patients – including the infamous Tuskegee study, where black men with syphilis were left untreated, even after penicillin.

She also said that the drug is known to lower men’s sperm, break off the women’s hair and turn the nails dark gray. For safety reasons, it is usually not given to pregnant women, although they may suffer from severe sickle-cell crisis.

Dr. Osunkwo said that she slowly exceeded the patient’s discouragement by letting them help in designing the trials.

“And” she added, “I would say that” being dead is worse than having dark nails. “”

In Africa 600 children were relatively easy, said Dr. Tshilolo, for Africans with sickle cell disease who had visited Europe had heard of hydroxyurea and knew it worked.

Sperm was obviously not a problem in a child’s attempt, he added. But African men usually used to use the drug when it was explained that the drips in the sperm count were relatively small and recovered when the drug was stopped.

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