The US opioid crisis continues to center, as the National Institute of Drug Abuse says more than 115 people die from an opioid overdose every day.

Doctors abuse 2016 opioid analgesic guidelines, federal officials said Wednesday, a clear response to increasing complaints from patients with chronic pain who say they are the victims of an over-reaction to the opioid crisis.

The Centers for Disease Control and Prevention, in new guidance for opioid writing, said many doctors were guilty of a “misapplication” of the 2016 guidelines that stuck to the use of opioids. The new guidelines, published in the New England Journal of Medicine, were the latest federal confirmation that many doctors responded to the opioid crisis went too far.

Former food and drug administration commissioner Scott Gottlieb, a doctor, spoke in July about the effects of the opioid crisis reaction on pain patients when he asked for more options to be developed.

Until then, people in the middle of cancer treatments with “acute sickle cell crises” or with post-operative pain should not be affected by the previous recommendations, CDC says. These patients were out of line with the guidelines, which were intended for primary care physicians who treated patients with chronic pain, the CDC noted.

Doctors abuse 2016 opioid painkillers guidelines, federal officials say.