A Chinese researcher claims he helped make the world's first genetically edited babies – twin girls whose DNA he said…
A Chinese researcher claims he helped make the world’s first genetically edited babies – twin girls whose DNA he said he changed with a powerful new tool capable of rewriting the very blueprint of life.
If true, it would be a profound leap of science and ethics.
Many mainstream scientists think it is too unsafe to try, and some denounced the Chinese report as human experimentation.
The researcher, He Jiankui of Shenzhen, said he altered embryos for seven couples during fertility treatments, with one pregnancy resulting
He said his goal was not to cure or prevent an inherited disease, but to try to bestow a trait that few people naturally have – an ability to resist possible future infection with HIV, the AIDS virus
He Jiankui, left, and Zhou Xiaoqin work a computer at a laboratory in Shenzhen, southern China. ” class=”Maw(100%)” src=”https://s.yimg.com/ny/api/res/1.2/zVCZL5h4bA2Y1MoMQUtz5Q–~A/YXBwaWQ9aGlnaGxhbmRlcjtzbT0xO3c9ODAw/http://media.zenfs.com/en-GB/homerun/pa_viral_news_704/f284075da9ccd2fd6e495e92c479c7ef” itemprop=”url”/>
He Jiankui , left, and Zhou Xiaoqin work a computer at a laboratory in Shenzhen in southern China (AP Photo / Mark Schiefelbein)
He said the parents involved declined to be identified or interviewed, and he would not say where they live or where the work was done.
There is no independent confirmation of Mr He’s claim, and it has not been published in a journal, where it would be vetted by other experts.
He revealed it on Monday in Hong Kong to one of the organizers of an international conference on gen editing that is set to start on Tuesday.
“He is told that it is not just to make a first, but also make it an example.” the AP.
Some scientists were astounded to hear of the claim and strongly condemned it.
Dr. Kiran Musunuru, a University of Pennsylvania gene editing expert and editor of a genetics journal, said it was “unconscionable … an experiment on human beings that is not morally or ethically defensible.”
“This is far too premature,” said Dr. Eric Topol, who heads the Scripps Research Translational Institute in California. “Vi handler med de driftsinstrukser om en menneskelig vesen. It’s a big deal. “
However, one famed geneticist, Harvard University’s George Church, defended attempting gene editing for HIV, which he called” a major and growing public health threat. “
In recent years, scientists have discovered
The tool, called CRISPR-cas9, makes it possible to operate on DNA to supply a required gene or disable one that is causing problems.
He Jiankui revealed his claims in Hong Kong to one of the organizers of an International Conference on Gene Editing (AP Photo / Mark Schiefelbein)
Editing sperm, eggs or embryos is different – the changes can be inherited. China outlaws human cloning but not specific gene editing.
Mr He studied at Rice and Stanford universities in the US before returning to his homeland to open a lab at Southern University of Science and Technology in China, where he also has two genetics companies.
The US scientist who worked with him on this project after he returned to China was physics and bioengineering professor Michael Deem, who was his adviser at Rice in Houston.
The Chinese researcher said he practiced editing mice , monkey and human embryos in the lab for several years and has applied for patents on his methods.
He said he chose embryo gene editing for HIV because these infections were a major problem in China. Han søgte at disable en gen hedder CCR5, der danner et protein, der tillader at HIV, det virus som forårsaker AIDS, kommer ind i en celle.
Alle de i projektet havde HIV og alle kvinderne gjorde ikke, men de gene editing was not aimed at preventing the small risk of transmission, Mr. He said.
Instead, the appeal was to offer couples affected by HIV a chance to have a child that might be protected from a similar fate.
He recruited couples through a Beijing-based AIDS advocacy group called Baihualin.
He said the gene editing occurred during IVF, or lab dish fertilization. First, sperm was “washed” to separate it from semen, the fluid where HIV can lurk. A single sperm was placed into a single egg to create an embryo. Then the gene editing tool was used.
When the embryos were three to five days old, a few cells were removed and checked for editing. Couples could choose whether to use edited or unedited embryos for pregnancy attempts. Eleven embryos were used in six attempts before the twin pregnancy was achieved, Mr. He said.
Tests suggest that one of the twins, born this month, had both copies of the intended gene altered and the other twin had just one altered,
Several scientists reviewed materials that Mr. He provided to the AP and said tests so far were insufficient to draw conclusions.
“I believe this is going to help the families and their children,” said Mr. He. Hvis det forårsaker uønskede bivirkninger eller skade, “Jeg ville føle den samme smerten som de gjør og det kommer til å være min egen ansvar”, la han til.