Categories: world

“Cannabis Disorder” treatment prevents sleep disorder in heavy users struggling to quit, experiment

An experimental drug that can help eliminate cannabis-abnormal symptoms that make it difficult for heavy users to quit being in…

An experimental drug that can help eliminate cannabis-abnormal symptoms that make it difficult for heavy users to quit being in demand because the legalization movement is accelerating, researchers have said.

Yale University researchers have found the treatment helped reduce withdrawal symptoms, such as sleep disturbances, anxiety and irritability – and reduced their use of cannabis more than patients receiving placebo.

The treatment works by preventing the decomposition of a chemical called anandamide, a cannabis-like endokannabinoid that occurs naturally in the body that acts on the same brain receptors as cannabis.

A much larger clinical trial is underway to get a better picture of its effectiveness before it can apply for licensing, but the researchers say that the first signs indicate that it can help users quit.

“With an increase in marijuana legalization efforts, it is reasonable to expect an increase in demand for treatment, and right now we have no medicines to help individuals try to quit,” said Professor Deepak Cyril D Souaz , one of the authors of the study.

“Many other drugs have been tested for their ability to reduce the use of cannabis and removal, but so far, no consistency has been shown to work against both withdrawal symptoms and relapses,” he admits.

There is a debate about how widespread cannabis addiction is, while it may cause psychological and physical symptoms of withdrawal. Many of the research is muddied by the fact that cannabis is smoked with tobacco in the head. [19659002] Current estimates are that 9 percent of users meet the criteria for cannabis addiction that the American Psychiatric Association defines as use that leads to risky behavior, functional or social deterioration and recall.

The world is considering this affecting 13 million people, but as many as one third of US users through certain assessments. More than 250,000 people were treated for the treatment of cannabis abuse in 2016, but only one failure achieves long-term recovery.

The results of the Yale researchers, published in the journal Lancet Psychiatry tested the treatment of 70 men, as drug toxicity has not been evaluated than smoking more than three managers per day on average.

It seems by inhibiting an enzyme called fatty acid amidhydrolase (FAAH) and allowing anandamide to build up, as the Yale researchers theorized could counteract cannabis deduction.

To test this, they saturated sleep patterns and cannabis use through urine tests and asked users to assess the quality of sleep, their mood and their desire.

Currently, substitution treatments have shown great success in withdrawal, but they often include drugs that can also be abused or increase the risk of relapse.

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Measurements made during sleep showed that patients receiving placebo began to get significantly less deep sleep at night, shortly after retardation began while the treatment group improved.

Professor D & # 39; Souza and his team suggest that this sleep disorder can be a key factor that undermines the patient’s ability to sleep.

Further tests are required to validate these results and to test things like memory or disability and how long lasting effects are, treatment is promising and it is unlikely that it leads to addiction.

“Anandamide is cannabis because endorphins are heroin,” said Prof D Souza. “

” Unlike cannabis or its main active participant delta-9 tetrahydrocannabinol (THC), FAAH inhibitors do not seem to have psychoactive or rewarding effects, and are therefore unlikely to be abused. “

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