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Can the annex be the key to Parkinson's disease?

FRIDAY, October 31, 2018 (HealthDay News) – Long belittled as insignificant, the attachment is hardly the rock star in the…

FRIDAY, October 31, 2018 (HealthDay News) – Long belittled as insignificant, the attachment is hardly the rock star in the body organs. However, its reputation may have an increase from new research indicating that removal of it can lower the risk of Parkinson’s disease.

The result follows an analysis that examined how drug removal (appendctomy) affected Parkinson’s risk among 1.6 million Swedish inhabitants. 19659002] The study could not be the cause and effect, but it appeared that appendectomy reduced Parkinson’s risk by about 20 percent.

“This is a tissue that most people consider to be unusable organs. It is attached to the large intestine, and it is removed as a very common surgical practice,” says study writer Viviane Labrie. She is neuroscience with the Center for Neurodegenerative Science at the Vanele Research Institute in Grand Rapids, Michigan.

The new results indicate that “the annex may be a tissue site that plays a role in the initiation of Parkinson’s disease.” She said.

Why? “The characteristic pathology of Parkinson’s disease in the brain is Lewy bodies characterized by a clumsy form of a protein called alpha synuclein, “Labrie explains.

In addition, lumps of this protein in the intestinal tract and are” present in the appendices to all of us “, some years before Parkinson’s symptoms occurred “she said.

So,” we believe that in rare cases [such protein clumps] would escape the annex and get into the brain, this could lead to Parkinson’s disease if. “In what way, just by raising the nerve that connects the intestinal tract directly to the brain,” said Labrie.

Parkinson’s attacks the nervous system and result in a progressive loss of both the motor function and many non-motor functions.

Common among the complications of Parkinson’s is the appearance of gastrointestinal dysfunction &#821

1; including constipation – which can effectively prevent motion loss for as much as 20 years. This indicated a potential link between Parkinson’s beginning and addition, researchers explained.

To investigate, researchers pointed to data such as previously collected by the Swedish patient registry. The registry is unique since since 1964 it has maintained a complete record of diagnoses and operations for a large part of the Swedish patient pool.

Of the 1.6 million patients treated more than 550,000 had undergone an appendctomy.

Following the Parkinson’s presence Mostly up to 52 years after the operation, investigators showed that Parkinson’s diagnosis was finally diagnosed in 1,2 out of 1,000 appenditomy patients, compared to 1.4 per 1000 people in the general Swedish population.

This meant that Parkinson’s risks had fallen by 19.3 percent among those who had removed their attachment.

After gaining the specific experience of 850 Parkinson’s patients, researchers decided that removal of the annex was also associated with a 3.6 year delay at the beginning of Parkinson’s treatment among those who had surgery and still developed the disease.

But Labrie still stressed that “we do not say having an appendix ix causes Parkinson’s disease, and that all people should go out and remove the attachment.”

We rather believe that what actually separates a person who continues to develop Parkinson’s from one that is not the prevalence of this pathology, but rather the factors that trigger the departure from the annex. “It gives rise to the possibility of developing new therapies designed to prevent such protein clubs from escaping from the annex.

The results were published in October 19th edition of Science Translational Medicine . Rachel Dolhun is Vice President of Medical Communication for the Michael J. Fox Foundation for Parkinson’s Research. She described the link between Parkinson’s and the annex as “particularly interesting.”

“But it’s important to emphasize that these are associations and not create causal relationships,” she said. “With others words with an appendectomy will not definitely reduce the risk of Parkinson’s. “

Dolhun added:” Investigating the relationship between bowel and brain can further lead to a deeper understanding of the causes of Parkinson’s like how Parkinson’s begins and progresses, and how to intervene to stop it But much work remains to be done.

More information

There is more on Parkinson’s disease at the Michael J. Fox Foundation for Parkinson’s research.

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