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Body fat levels linked to breast cancer risk in postmenopausal women

"We find that excess body fat in those who are postmenopausal with a normal body mass index is associated with…

“We find that excess body fat in those who are postmenopausal with a normal body mass index is associated with about a doubling in the risk of estrogen-dependent breast cancer,” said Dr. Andrew Dannenberg, a study author and director of Cancer Prevention at Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.

The American Cancer Society states that estrogen-dependent cancer called ER positive breast cancer in the study occurs when the receptor proteins in or on the cells attach the hormone estrogen and rely on it to grow.

The researchers studied 3,460 American women between the ages of 50 and 79 who had crossed menopause. The women were part of women’s health initiatives and had their body composition measured at the beginning of the program, said Dannenberg. Of these women 1

46 ER positive breast cancer developed, and the researchers were looking for a relationship between excess body fat and the development of this cancer.

They found that an increase of 5 kg (11 pounds) in whole body fat mass was associated with a 35% increased risk of this type of breast cancer. A 5 kg increase in body fat fat mass was associated with a 56% increase in risk.

Tribal fat is “defined by fat in torso apart from head and leg”, according to the study.

The study also found that for an invasive breast cancer that has spread in the surrounding breast tissue, a 5-kilo increase in whole body fat mass was related to a 28% risk increase. The same increase in trunk fat was tied to a 46% increase in the risk of invasive breast cancer.

“The most important removal is to have excess body fat, even if you have a normal body mass index, is associated with increased risk of breast cancer,” says Dannenberg.

A person’s BMI is calculated by a formula that includes their height and weight. The “normal” BMI is considered to be between 18.5 and 24.9, according to the study.

The researchers also looked at blood data taken at the beginning of the Women’s Health Initiative for other factors that are known to play a role in development of breast cancer, such as raising insulin molecules.

The results emphasize the importance of research that distinguishes the contribution of body size, body composition and metabolic profiles for breast cancer risk, Dr. Isabel Pimentel, Ana Elisa Lohmann and Pamela J. Goodwin wrote in a editorial published next to the study.

The editorial authors also point out that other researchers have looked at the subject with different results and note that “these obs Inheritance suggests that components of metabolic health, rather than the presence of complete metabolic syndrome, can contribute to the risk of breast cancer. “

 How much a decade of obesity increases your cancer risk

A special strength in the research of Hoda Anton-Culver, distinguished professor at the Medical Department at the University of California, Irvine, was the analysis of the body’s body fat levels.

“I think it’s a good step forward that takes us from looking at BMI as an indicator of obesity to really look at the specific site of fat concentration in the body,” says Anton-Culver, who was not involved in research.

Researchers have shown that there was a link between obesity and cancer, but Anton-Culver says that the new study moves research beyond the general association.

“They say correctly in the summary that obesity is associated with breast cancer, but more specifically, obesity around the abdomen is more specific to the association,” she said.

Although Anton-Culver thinks the research is strong, she pointed out that she only looked at a specific cancer.

“I do not know if we look at the same problem with other cancers as the result, what it will be, is it specific for breast cancer?” She said. “We have to ask that question next, because obesity is a risk factor for other cancers.”


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