The test was developed after researchers from the University of Queensland found that cancer forms a unique DNA structure when…
The test was developed after researchers from the University of Queensland found that cancer forms a unique DNA structure when placed in water.
The test works by identifying the presence of that structure, a discovery that can help detect cancer in humans far earlier than current methods, according to the paper published in the journal Nature Communications.
“Discovering that carcinogenic DNA molecules are formed completely different 3D nanostructures from normally circulating DNA was a breakthrough that has enabled a whole new approach to detecting cancer that is not invasive in any tissue type, including blood,” said Professor Matt Traced in a statement.
“This led to cheaper and portable detection devices that could ultimately be used as a diagnostic tool, possibly with a mobile phone,” he added.
Researchers around the world have worked in ways to identify cancer earlier, as early detection is known to increase the success rate of therapeutic treatment and surgery.
Earlier this year, researchers at John Hopkins University in the United States announced that they had developed a blood test called CancerSEEK, which screen for eight common cancers. That test identifies the presence of cancer proteins and gene mutations in blood samples. M Indeed, more research has to be done before the test can be used to a large extent, US scientists allow.
0-minute test developed in Australia is not yet applicable to humans and major clinics.
So far, the signs are positive.
Test on more than 200 tissues and blood samples detected cancer cells with 90% accuracy, researchers said.
As far as it has only been used to detect breast, prostate, intestinal and lymphoma but they are convinced that the results can be replicated with other types of disease.
“Researchers have long been looking for a common form of cancer for developing a diagnostic tool that can apply to all types,” wrote Trau and his research partners Abu Sina and Laura Carrascosa in an article for academic news site The Conversation.
Cancer changes the DNA of healthy cells, especially in the distribution of molecules called methyl groups, and the test detects this altered pattern when placed in a solution like water.
“Using a high resolution microscope, we found that cancerous DNA fragments fell into three-dimensional structures in water. These differ from what we saw with common tissue DNA in the water,” the article says.
The test uses gold particles that binds with cancer-affected DNA and “can affect molecular behavior in a way that causes visible color changes.”
The next step for the team is to conduct clinical studies on how early cancer can be detected and if the test can be used to measure the effectiveness of treatment.
They also look at the possibility of using different body fluids to detect different types of cancer from early to later stages of the disease.