MUNICH (Reuters) – An AstraZeneca drug that blocks a cancer cell's ability to repair its genetic code greatly reduced the…
MUNICH (Reuters) – An AstraZeneca drug that blocks a cancer cell’s ability to repair its genetic code greatly reduced the risk of ovarian cancer worsening in a phase III trial, underpinning its lead against two U.S. rivals in the same class.
FILE PHOTO: A sign is seen at an AstraZeneca site in Macclesfield, central England May 1
9, 2014. REUTERS / Phil Noble / File Photo
Given as a maintenance therapy to strengthen initial chemotherapy, Lynparza halted or reversed tumor growth in 60 percent of patients three years into the trial. Slechts 28 procent van die in een chemotherapie-alleen controle groep waren sparen tumorprogressie in die fase.
At year four, the progression-free survival rate (PFS) in the Lynparza group was still above 50 percent, against 11 percent for chemotherapy alone.
“The results … herald a new era in treatment for women diagnosed with advanced ovarian cancer who carry a BRCA mutation,” said Kathleen Moore, associate professor at the University of Oklahoma’s Stephenson Cancer Center, who presented the results at the European Society for Medical Oncology in Munich on Sunday.
Cancer cells with the so-called BRCA mutation have a diminished ability to restore their DNA when it gets damaged during cell division, which is a driver behind cancerous mutations.
Lynparza and other drugs in the class of so-called PARP inhibitors are designed to block what remains of that DNA repair mechanism so that BRCA-mutated cancer cells fail to replicate and the tumor can no longer sustain itself.
The drug, already approved for later use in patients with BRCA mutations and for a particular type of breast cancer, was the first PARP inhibitor to reach the market when it won U.S. godkendelse til slutten av 2014, men nu står konkurrenter fra produkter lavet af Tesaro og Clovis Oncology.
British drug maker AstraZeneca, which published some initial information on the trial in June, generated $ 297 million in Lynparza sales last year. Analysts on average see $ 2 billion in revenue from the drug in 2023, Refinitive data shows.
The result should pave the way for expanded use of the medicine, which is being developed and marketed with Merck & Co during a deal struck last year, and AstraZeneca is in agreement with regulators about approval procedures.
Getting patients on Lynparza at a early stage of treatment, so-called first-line use, puts AstraZeneca in the frame to secure longer-duration prescriptions.
Clovis Oncology’s Rubraca has been approved for ovarian cancer after initial chemotherapy has failed. Tesaro, meanwhile, expects to report trial results for the first-line use of its Zejula drug for ovarian cancer next year.
Pfizer’s PARP inhibitor talazoparib received approval for a subtype of advanced breast cancer this week.
Reporting by Ludwig Burger; Editing by David Goodman
Our Standards: The Thomson Reuters Trust Principles.