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Another study found a link between Parkinson's disease and the annex. What is going on?

Lumps of proteins found in the brain of people who have Parkinson's disease are also elsewhere in the body – inside the annexes to healthy people. This result has led researchers to study the connection between the appendix and the risk of developing Parkinson's. A study from October 2018 showed that removal of the appendix was associated with a reduced risk of developing the disorder, Live Science reported. But new results indicate the opposite. Removing the appendix is ​​associated with an increased risk of developing Parkinson's. The study, which has not yet been published in a peer-reviewed journal, will be presented later this month at Digestive Disease Week, a scientific meeting focusing on digestive diseases. [3 Myths About Parkinson&#821 7;s Disease] The new study looked at data on more than 62 million patients using a database of records from 26 major healthcare systems across the United States. The researchers identified patients who had appendctomies – surgery to remove the annex – and flagged those who continued to develop Parkinson's disease at least six months later. The researchers found that 4,477 (0.9%) of the over 488,000 patients who removed their attachments continued to develop Parkinson's disease. Of the remaining 61.7 million patients who did not have appendectomies, only about 177,000 (0.3%) later developed Parkinson's. The results indicate that the risk of developing Parkinson's disease is about three times higher for people who had appendectomy than those who did not, regardless of age, gender or race. But senior author Dr. Gregory Cooper,…

Lumps of proteins found in the brain of people who have Parkinson’s disease are also elsewhere in the body – inside the annexes to healthy people.

This result has led researchers to study the connection between the appendix and the risk of developing Parkinson’s. A study from October 2018 showed that removal of the appendix was associated with a reduced risk of developing the disorder, Live Science reported.

But new results indicate the opposite. Removing the appendix is ​​associated with an increased risk of developing Parkinson’s. The study, which has not yet been published in a peer-reviewed journal, will be presented later this month at Digestive Disease Week, a scientific meeting focusing on digestive diseases. [3 Myths About Parkinson&#821

7;s Disease]

The new study looked at data on more than 62 million patients using a database of records from 26 major healthcare systems across the United States. The researchers identified patients who had appendctomies – surgery to remove the annex – and flagged those who continued to develop Parkinson’s disease at least six months later.

The researchers found that 4,477 (0.9%) of the over 488,000 patients who removed their attachments continued to develop Parkinson’s disease. Of the remaining 61.7 million patients who did not have appendectomies, only about 177,000 (0.3%) later developed Parkinson’s.

The results indicate that the risk of developing Parkinson’s disease is about three times higher for people who had appendectomy than those who did not, regardless of age, gender or race.

But senior author Dr. Gregory Cooper, a professor of medicine at Case Western Reserve University in Cleveland, said “this is still an association” and not a cause-and-effect discovery. In other words, the study does not show that the removal of the annex causes Parkinson’s.

One possible explanation for the increased risk found in the study is that during an appendectomy, a specific substance – alpha-synuclein proteins – is released to the body and travels up to the brain, Cooper said. These proteins are known to form clumps called Lewy bodies – a narrative sign of Parkinson’s disease.

Still, this explanation is “speculative,” Cooper said to Live Science.

Viviane Labrie, an assistant professor of neuroscience at the Van Andel Research Institute in Michigan who was not part of the new research, noted that the study “does not have a long follow-up window”. That means researchers could only link appendctomies to the beginning of Parkinson’s movement problems, she said.

But these movement problems or motor symptoms do not really represent the onset of the disease, says Labrie to Live Science. Rather, Parkinson’s disease has about 20 years of “prodromal period” before these symptoms occur. During this time, other less obvious symptoms may occur.

During the prodromal period, for example, people with Parkinson’s symptoms may occur as constipation or other digestive problems, Labrie said. However, things further complicate, these symptoms may increase the risk of appendicitis – the inflammatory condition leading to an appendectomy. So, it is possible that prodromal symptoms of Parkinson’s disease may cause appendicitis and subsequent surgery, and not additional removal that causes Parkinson’s disease, she said.

Labrie was a senior author of a study published in October 2018 in Science Translational Medicine, which used data from a Swedish database of more than 1.6 million people who tracked patients for up to 52 years. The report showed that people who had removed their attachment when they were young were 19% to 25% less likely to develop Parkinson’s later in life.

“The main difference between [the Swedish] study and [US] study is the time that patients were followed,” said Labrie.

Cooper agreed that a limitation of his study contained limited data available during the follow-up period This was because the patient information was identified, so researchers could not see how long it required specific patients to develop Parkinson’s after an appendectomy, but since the database has been collecting data since 1997, at least some of the patients were followed for nearly 30 years, he said. 19659002] In addition, researchers did not have access to patient records, so they could not look at other factors that may have affected the results, such as specific symptoms or medications, added Cooper.

Ultimately, there is still no agreement on appendectomies is associated with a higher risk of Parkinson’s disease.

2016 study published in the journal Movement Disorders found similar results for this new study – that an appendectomy was associated with an increased risk of Parkinson’s disease risk 10 or more years after surgery; but that risk was much less than that noted in the latest study. Other research, such as a 2018 paper published in motion disorders, found little or no association between appendectomy and Parkinson’s disease.

Nevertheless, Cooper emphasized that while the study found a link between an appendectomy and the risk of developing Parkinson’s disease, the risk is very low: Less than 1% of people who developed Parkinson’s disease had undergone an appendectomy, he said.

“I don’t want people to come from here and say,” Well, I have appendicitis I won’t get my attachment extracts because I don’t want Parkinson’s disease, “he said.” If you have appendicitis … you get your attachment out. “

This is reminiscent of what Labrie said to Live Science this fall, when her paper was published:” One of the things we do not want to get over to people is that [they] should have preventive appendectomy or that just because you have an attachment, you will get Parkinson’s disease. “

Originally published on Live Science .

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