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A health issue for the future? Pharmaceutical Society of Singapore raises alarm on antibiotic resistance

November 17, 2018 Health 1 Views SINGAPORE: As a General Practioner (GP) with 20 years' experience, Dr Lye Tong Fong…

SINGAPORE: As a General Practioner (GP) with 20 years’ experience, Dr Lye Tong Fong has with all types of patients. Bland dem er de som krever antibiotika når de ikke er nødvendige eller effektive.

Sometimes they come in with “very minor symptoms” like a fever or a slight runny nose, Dr. Lye told Channel NewsAsia at his clinic in Pasir Rice.

“When they come in, the first thing They say is ‘Doctor, I need antibiotics’. There are no grounds for you to explain and use logic with them, “he said.

If they demand them, he may give the patients the antibiotics.

” But I will tell them the situation in which they should start on the course. I think that’s the best you can do next to fighting with them and having a drama in the clinic, “he said.

For example, if the disease persists beyond one week with fever and discharge containing mucus and pus, they could

Advertisement There are many symptoms, such as a sore throat, cough or runny nose, which are often caused by viruses and therefore not treatable with antibiotics.

Dr. Lye tells patients when they do not need antibiotics, and they are convinced. (19659002) Bacteria carried by people build resistance to antibiotics when repeatedly exposed to them. Eventually, people grow immune to these antibiotics, and may not respond to them.

File photo of antibiotics.

But still, a 2016 study conducted by the National University of Singapore found that four in five patients with upper respiratory tract infections, which cause symptoms such as runny nose and sore throats , vet ikke at antibiotika kan ikke bidra til at lindre deres tilstand.


The WHO said earlier this year that antibiotic resistance is “rising to dangerously high levels in all parts of the world “and is one of the biggest threats to global health, food security, and development today.

” Without urgent action, we are heading for a post-antibiotic era, in which common infections and minor injuries can once again, “the global health authority warned.

Closer to home, the Pharmaceutical Society of Singapore has sounded the same warning.

Speaking to Channel NewsAsia, members of the society Dr. Andrea Kwa, a clinician scientist and specialist pharmacist (infectious diseases) at the Singapore General Hospital, and Dr. Jonathan Seah, senior principal clinical pharmacist at Changi General Hospital, painted a bleak picture of the future should the situation not change.

“Aggressive treatments that we have been employing we can not do anymore, because the treatments will knock out your immune system. Whatever infections you are exposed to may kill you, “Dr. Seah said.

Having resistant bacteria means that health professionals will have to use stronger antibiotics, broader spectrum antibiotics, combination antibiotics or more toxic versions in order for them to work, Dr. Seah cautioned.


The urgency of the problem comes against a backdrop of slowing antibiotic production by pharmaceutical companies and bacteria that have become resistant to many types of drugs. 19659002] In July this year, Novartis, one of the world’s largest drug makers, announced the end of its antibacterial and antiviral research, joining other pharmaceutical companies like AstraZeneca, Sanofi and Allergan. Another industry giant GlaxoSmithKline has put some antibiotics assets under review.

“In terms of money making, it’s harder to make money from antibiotics. Business-wise, it’s hard for them to justify (making antibiotics), “Dr Seah said.

A superbug resistant to all known antibiotics that kan forårsake “alvorlige” infektioner eller døden er spredt undetected via hospitaler over hele verden, forskere har advaret AFP / JORGE DIRKX

Da det kan ta 15 år å komme med en ny sammensætning, gå igjennom alle trinnene i forskning and clinical trials, and then have it registered for use, it is possible that at the time the drug comes out, it could be ineffective, he added.

Dr. Kwa also said the reality is that producing drugs for longer-term and chronic diseases are more profitable for these pharmaceutical companies, as antibiotic usage is limited to a few days each time.

She added that new antibiotics are being produced, but they are not able to cover all the resistant bugs.

“They are all Just a little bit better or a little bit different from what we have.


and if you have a very good antibiotic, once you come on board, you use it, you misuse it, resistance will happen. ] The pharmacists suggested that GPs use diagnostic kits that rule out bacterial infection so that antibiotics are not prescribed unnecessarily. Mens de koster omkring S $ 10 hver, investing in these kits is “better than paying for the cost of taking antibiotics,” Dr. Kwa said.

There is also a need to change the mindset of the public, as the expectation that they need antibiotics could be influencing GPs, Dr. Kwa said.

The Health Promotion Board, which introduced a public education campaign entitled Use Antibiotics Right in October 2018, said there is a need to educate people on the correct use of antibiotics, which should “The campaign serves to remind the public that antibiotics do not help with upper respiratory tract infections, which may be prone to during the flu season, and to have their doctor’s advice before taking antibiotics, “a spokesperson said.

In response to queries from Channel NewsAsia, the Ministry of Health (MOH) said education of both doctors and patients is important to generate awareness of and action against antimicrobial res


An additional factor to consider is that some GPs may prescribe antiobiotics for financial reasons, Dr Kwa said. She suggested that the desire to keep patients happy so that they keep returning could affect some GPs.

Dr. Lye Tong Fong at the Central 24-hour Clinic in Pasir Rice. (Photo: Jalelah Abu Baker)

Dr. Lye acknowledged that some doctors prescribe antibiotics “rampantly” because of business concerns but this is not prevalent, he said.

The Pharmaceutical Society thinks that if GPs prescribe antibiotics, but not dispense them, the situation could improve. Dit is omdat patiënten zouden moeten gaan naar een andere locatie om hun behandeling te ophalen, eerder dan het verzamelen van hun clinic’s apotheek.

Deze afbakening van de receptie en afgifteprocessen is al in de praktijk in landen zoals de Verenigde Staten, Zuid-Korea

“In fact, they have more multi-resistant bacteria. So that practice does not guarantee a better prescription of antibiotics, “he said.

In fact, profits will shift from the doctors side to pharmacies instead, he countered.

” The only thing that delinking will do is cause the patient some inconvenience, “he said.

MOH also said that delinking prescription from dispensing may not necessarily reduce the use of antimicrobials like antibiotics.

While antibiotics can only be prescribed by qualified and licensed doctors and are not available for over -the-counter purchase, MOH will “continue to work with stakeholders to enhance the surveillance of antimicrobial resistance and improve stewardship of antimicrobial use,” a spokesperson said.


While they suggested solutions to improve the situation, the pharmacists stressed that prevention was better than treatment. To this end, Dr Seah urged the public to maintain hand hygiene

Woman getting her flu vaccine. “/>

Woman getting her flu vaccine. (Photo: Unsplash / Hyttalo Souza)

They also encouraged more people to go for vaccinations. Primary care providers can also take a more proactive role in promoting vaccinations, Dr. Kwa said.

Still, there is a need to curb current antibiotic overuse and misuse. Dr Kwa stressed the possible dire consequences. There is “a lot of cost if you take an antibiotic in an inappropriate manner,” she said.

“This cost may not be obvious to you now, but it will come back to haunt you one day. Humans are very myopic. When it does not haunt you immediately, it’s out of the mind, “she said.

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